Explore the characteristics of cancer with the CELLOGER Mini real-time analysis.
Cancer characteristics are continuously changing. Real-time analysis of tumour biology is helping to shed new light on the behaviour of many cancers, as well as providing new pharmacological targets and treatment strategies.
Advances in oncology are driven by technological advances, and the last decade has seen huge advances in live cell testing, using both traditional 2D techniques and advanced 3D cell culture models.
By offering the possibility to study cancer cell biology over time, with powerful analysis capabilities, the CELLOGER Mini system provides valuable information in the field of oncology research.
They chose the CELLOGER Mini
The Inserm UA7 unit, Synchrotron Radia for Biomedicine, also associated with Grenoble Alpes University, the European Synchrotron Radiation Facility (ESRF) and Grenoble Alpes University Hospital (CHUGA), is headed by Professor Sam Bayat (PU-PH, CHUGA, Grenoble) and aims to develop biomedical applications of synchrotron radiation, ranging from the exploration of sub-cellular structure and composition to patient imaging and radiotherapy.
“The acquisition of an automated real-time live cell imaging system inside the incubator, CELLOGER mini, will accelerate our research by obtaining more physiologically relevant information on the cells studied, as well as real-time kinetic data. R. Serduc and S. Bohic
Innovative radiotherapy methodology
R.Serduc, Inserm researcher, is working on an innovative radiotherapy methodology for the treatment of cancers (spatially fractionated radiotherapy by X-ray microbeams) and developed with the European synchrotron of Grenoble ESRF.
The CELLOGER mini system is compact, flexible in terms of dedicated applications, can be easily decontaminated and allows an easy work in a hypoxia incubator or not. It is placed close to the X-ray source, as we need to avoid artefacts due to transport, temperature changes (which cause significant cell stress) and reduce the time between irradiation and imaging sessions.
Finally, the study of cellular models under different conditions will allow us to study without disturbance the invasion capacity of tumour cells, the evolution of tumour angiogenesis under different irradiation conditions, the immune response…
Understanding mechanisms of action
S.Bohic, Inserm researcher, is working on understanding the mechanisms of action of new organometallic transition metal complexes developed by Professor Jaouen (CNRS team, ChemBio, at Sorbonne University, Paris) and which have very promising results on cancers that are very difficult to treat with the current therapeutic arsenal, notably triple-negative breast cancer cells.
The CELLOGER mini system will therefore enable us to understand the mechanism of action of these new compounds more quickly by imaging a certain number of markers of interest to us for this type of cell exposed to treatment 24 hours a day.
The European Synchrotron Radiation Facility (ESRF), a civil company under French law created on 12 January 1989, is one of the largest synchrotrons currently in operation in the world.
Delivered to scientists at the beginning of 1994, this particle accelerator with a circumference of 844 metres, which allows the exploration of matter and life at the atomic level, is financed by 22 member countries and hosts nearly 7 000 researchers each year.